Possible Development of Resistance to Fluconazole During Suppressive Therapy for AIDS-Associated Cryptococcal Meningitis
نویسندگان
چکیده
منابع مشابه
Editorial response: A comparison of itraconazole versus fluconazole as maintenance therapy for AIDS-associated cryptococcal meningitis.
Fluconazole at a dosage of 200 mg daily has again been is effective, while those with persistent urinary cryptococcosis should receive at least 400 mg daily of fluconazole. demonstrated to be highly effective in reducing the risk of relapse after recovery from cryptococcal meningitis [1]. UnforAn interesting note in the clinical study reported by Dr. Saag and colleagues was the possible adjuvan...
متن کاملFluconazole-resistant cryptococcal meningitis.
A 40-year-old HIV-positive man was admitted to Cecilia Makiwane Hospital in December 2001 with a history of severe headache, photophobia and fever. Indian ink staining of cerebrospinal fluid (CSF) revealed yeast cells with 3 5 budding forms per high-power field. A diagnosis of cryptococcal meningitis was made and the patient was started on amphotericin B. He reacted to this almost immediately, ...
متن کاملEmerging fluconazole resistance: Implications for the management of cryptococcal meningitis
We present the case of an HIV-seropositive individual with cryptococcal meningitis who was found to have a fluconazole resistant strain of Cryptococcus neoformans. The individual required multiple rounds of amphotericin and fluconazole 800-1200 mg after several episodes of clinical relapse. Cerebrospinal fluid sterilization was achieved and maintained with high doses of fluconazole. This case d...
متن کاملUse of high-dose fluconazole as salvage therapy for cryptococcal meningitis in patients with AIDS.
Eight patients with AIDS were treated orally with 800 mg of fluconazole daily for cryptococcal meningitis for a mean duration of 4.5 months. Previous antifungal treatment had failed for all of the patients. No major toxicity was observed. Three patients died from cryptococcal infection. High-dose fluconazole may be effective salvage therapy for cryptococcal meningitis.
متن کاملFluconazole alone or combined with flucytosine for the treatment of AIDS-associated cryptococcal meningitis.
An all oral treatment for cryptococcal meningitis is attractive, particularly where amphotericin B use is impractical. Both fluconazole and flucytosine are available in oral formulations and have activity against Cryptococcus neoformans. We conducted a prospective phase II dose escalation study employing doses of fluconazole ranging from 800 to 2000 mg daily for 10 weeks used alone or combined ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 1996
ISSN: 1058-4838,1537-6591
DOI: 10.1093/clinids/23.6.1337-a